RESUMO
Background: Visfatin is a novel adipocytokine, secreted by the visceral fat of humans and mice. Its level increases in plasma during progression of diabetes and development of obesity. The objective of study was to determine the levels of visfatin in obese and diabetic BALB/c strain of albino mice
Methods: It was a quasi experimental study. Ninety BALB/c strain albino mice were procured from NIH, Islamabad and divided into three groups. Animals in Group I [n=30] were grown obese by feeding high fat/high carbohydrate diet whereas Group II [n=30] were turned insulin dependent diabetic by injecting streptozotocin. Group III [n=30] served as control. Blood samples were collected to measure the blood glucose, lipid and visfatin levels. Visfatin levels were measured by enzyme-linked immunosorbent assay [ELIZA], and p
Results: Visfatin levels were significantly raised in obese and diabetic mice
Conclusion: Diabetes Mellitus and obesity are strongly associated with increased serum visfatin levels in BALB/c strain of albino mice
RESUMO
Objective: This study was carried out to assess the vitamin A supplementation status inpediatric measles patients
Study DesignrAnalytical study
Place andDuration of Study: This study was conducted at Pediatric Department of Women and Children Hospital, Abboatabd from January 2014 to December 2014
Materials and Methods: Detailed history and physical examination of 200 patients was recorded in a pro forma
Vitamin A supplementation and vaccination status were recorded along with demographic profile
Results: 103 [51.5%] were males and 97 [48.5%] were females- Majority of these patients [55.5%] were residents of rural area of Abbottabad district. 77% of the children were low weight. The mean age of the children was 37 +/- 9 months. Out of 173 patients who were eligible for vaccination, only 34.5 % of the patients were vaccinated for measles, and 47% of the eligible patients did not receive measles booster dose. 79% of the patients did not receive vitamin A supplementation in the last 6 months. Conjunctivitis [86%] and oral ulcers [73.5%] were the most common complications
Other complications included pneumonia [25.5%], diarrhea [19.5%], congestive cardiac failure [1%], epistaxis [1%], otitis media [0.5]
Conclusion: Majority of the patients did not receive vitamin A supplementation. The most common complication were conjunctivitis and oral ulcers, which can be associated with vitamin A deficiency during measles
RESUMO
Objectives: To determine the frequency of anemia in children of Hazara Division
Study Design: Cross-sectional / observational study
Place and Duration of Study: This study was carried out at thePediatric Outpatient of Ayub Teaching Hospital Abbottabad from 1[st] January,2015 to 30[th]June,2015
Materials and Methods: Three hundred and seventy five children were selected randomly using random number tables from Hazara Division coming to Pediatric Outpatient of Ayub Teaching Hospital Abbottabad. Their age range was 0-18 years.Their diagnoses were ascertained, recorded and analysed
Results: Majority of the patients were male and were in the age-range of 2-10 years.Anemia was present in 3.9999 % of children.Iron deficiency anemia was the most common cause of anemia in these children
Conclusions: Majority of the children were male and were in the age range of 2-10 years.Anemia was present in 3.9999% of these children and iron deficiency was the most common cause of it
RESUMO
Beta-sitosterol is a naturally occurring plant sterol [phytosterol] present in many fruits and vegetables. Scientific research has proven that beta-sitosterol is helpful in maintaining the proper functioning of our body. Previously we described the complexation of beta-sitosterol with trace metals [Mahmood et al., 2013]. Trace metals after the formation of complex unable to absorb in the body and hence eliminated out from the body thus reducing metal toxicity [Marsha, 1996]. The present article describes the complexation of beta-sitosterol with Palladium [Pd] metal. Palladium is a toxic metal and due to polluted and hazardous environment traces of this metal can be transferred into the body, which is harmful for human health. Our aim is to make Pd-sterol complex so that this toxic metal [Pd] does not absorb in the body and hence excreted out from the body in the complex form. In order to form this complex beta-sitosterol [Ib] is reacted with Tris [dibenzylideneacetone] dipalladium or [Pd[2] [DBA][3]] [Ia] in 2:1 ratio in an inert atmosphere and dimethylformamid [DMF] added as a solvent. The resulting complex [Pd[2] [DBA][3].[beta-sitosterol] [Ic] was identified by various spectroscopic techniques such as IR, Mass and [1]H-NMR. This new organo metallic complex [Ic] also showed significant antibacterial and antifungal activity. The present work revealed that Pd-sterol complex does not only reduce metal toxicity but also helpful in minimizing bacterial and fungal infections present in the body. Our research also concluded that we must take plenty of fruits and vegetables in our diet so that natural plant sterol such as beta-sitosterol can enhance our defense mechanism and maintain other functions of our body